Prof. Holick zu den präventiven Vitamin D Spiegel
Is it necessary to have vitamin D levels between 60-80ng/ml to prevent cancer?Response: It does appear that when the blood level of 25(OH)D is at least 30 ng/ml that it may decrease risk of many deadly cancers. It is unknown, however, the blood level needs to be 60 ng/ml. There is no harm in keeping the blood level at between 60 and 80 ng/ml. Ihave all of my patients on enough vitamin D to maintain their bloodlevels between 40 and 100 ng/ml which I believe to be both therapeuticand preventative for chronic diseases including common cancers.
Rhee HV, Coebergh JW, Vries ED.
Sunlight, vitamin D and the prevention of cancer: a systematic review of epidemiological studies.
Department of Dermatology, Hagaziekenhuis, Den Haag bDepartment of Public Health, Erasmus MC, Rotterdam cEindhoven Cancer Registry, Comprehensive Cancer Centre South, Eindhoven, The Netherlands.
Abstract: The number of studies reporting beneficial effects of sunlight and vitamin D on several types of cancer with a high mortality rate is growing rapidly. Present health recommendations on sun exposure are mainly based on the increased risks for skin cancer. We reviewed all published studies concerning cancer and sun exposure and vitamin D, respectively, excluding those about skin cancer. Most identified ecological, case-control and prospective studies on the incidence and mortality of colorectal, prostate, breast carcinoma and non-Hodgkin lymphoma reported a significantly inverse association with sun exposure. The results of the included studies on the association between cancer risk and vitamin D were much less consistent. Only those studies that prospectively examined the 25-hydroxyvitamin D serum levels in relation to risk of colorectal cancer are homogeneous: they all reported inverse associations, although not all reaching statistical significance. The results of the intervention studies are suggestive of a protective role of high doses of vitamin D in cancer, but they have been criticized in the literature. We, therefore, conclude that there is accumulating evidence for sunlight as a protective factor for several types of cancer. The same conclusion can be made concerning high vitamin D levels and the risk of colorectal cancer. This evidence, however, is not conclusive, because the number of (good quality) studies is still limited and publication biases cannot be excluded. The discrepancies between the epidemiological evidence for a possible preventive effect of sunlight and vitamin D and the question of how to apply the findings on the beneficial effects of sunlight to (public) health recommendations are discussed.EuSkin cancer prevention and UV-protection: how to avoid vitamin D-deficiency?
J. Reichrath
Article first published online: 22 SEP 2009
© 2009 The Author. Journal Compilation © 2009 British Association of Dermatologists Issue
British Journal of Dermatology
Special Issue: Advances in the Management of UVR induced Skin Cancers.
Volume 161, pages 54–60, November 2009
Summary
Because solar UV-radiation represents the most important environmental risk factor for the development of non-melanoma skin cancer, UV protection is important to prevent these malignancies. Consequently, public health campaigns were developed to improve the knowledge of the general population regarding the role of UV-radiation for the development of skin cancer. However, it has to be noted that vitamin D-mediated positive effects of UV light were not adequately considered in most of these campaigns, that often propose a strict ‘no sun policy’ without giving recommendations how to prevent vitamin D-deficiency. Under our living conditions, approximately 90% of all vitamin D needed by the human body has to be formed in the skin through the action of UV-B-radiation and it has been shown that strict sun protection causes vitamin D-deficiency. This dilemma represents a serious problem, for an association of vitamin D-deficiency and multiple independent diseases including various types of cancer, bone diseases, autoimmune diseases, infectious diseases, cardiovascular diseases and hypertension has now been reported in a large number of laboratory and epidemiologic investigations. Although further work is necessary to define an adequate vitamin D-status and adequate guidelines for UV-exposure, it is at present mandatory that guidelines for UV-exposure (e.g. in skin cancer prevention campaigns) consider these facts and give recommendations how to prevent vitamin D-deficiency. At present, most experts in the field agree that the evidence to date suggests that daily intake of 1000–2000 IU vitamin D could reduce the incidence of vitamin D-deficiency-related diseases with minimal risk in Europe, the US, and other countries. In this review, we analyze the present literature to help developing well-balanced guidelines on UV-protection that ensure an adequate vitamin D-status. These recommendations will hopefully protect us against vitamin D-deficiency without increasing the risk to develop UV-induced skin cancer.Summary Volume 161, pages 54–60, November 2009Special Issue: Advances in the Management of UVR induced Skin Cancers.British Journal of Dermatology© 2009 The Author. Journal Compilation © 2009 British Association of Dermatologists Issue Article first published online: 22 SEP 2009J. ReichrathSkin cancer prevention and UV-protection: how to avoid vitamin D-deficiency?
Lappe und Kollegen zeigten in einer Doppelblind-Studie, dass un-
ter der Einnahme von Vitamin D weniger neue Krebskrankheiten
auftraten.Vitamin D and calcium supplementation reduces cancer risk:
results of a randomized trial 1,2
Joan M Lappe, Dianne Travers-Gustafson, K Michael Davies, Robert R Recker, and Robert P Heaney
Interventionsstudie Calcium 1500mg + Vitamin D3 1100IE senken in einer Doppelblindstudie von 4y in USA, bei Frauen nach der Menopause das Krebsrisiko für fast alle Krebsarten um 40%